Svensson, B, Ekström, P & Edström, A 1995, ' Okadaic Acid and Cultured Frog Sciatic Nerves: Potent Inhibition of Axonal Regeneration in Spite of Unaffected Schwann Cell Proliferation and Ganglionic Protein Synthesis ', Journal of Neurochemistry, vol. 64, nr. 3, s. 1000-1007.

Avhandlingens titel: Effects, dynamics and management of okadaic acid in blue mussels, MYTILUS EDULIS. Avhandlingen framlagd vid: Göteborgs universitet, 

It has also been isolated from another marine sponge, H. malanodocia, as a cytotoxin. Okadaic Acid. Okadaic acid (or okadeic acid, CAS 78111-17-8, C44 H 68 O 13) is produced by dinoflagelates Dinophysis sp. and Prorocentrum lima. Lipophilic okadaic acid is a potent inhibitor of protein phosphorylase phosphatase-1 and -2A in the cytosol of the mammalian cells that dephosphorylates serine and threonine. Okadaic acid, 97% | C44H68O13 | CID 131839562 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological Okadaic acid is an inhibitor of the serine/theorine protein phosphatases PP1 (IC 50 = 15-20 nM) and PP2A (IC 50 = 0.1 nM), exhibiting much greater activity towards the latter.

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Taken together, these results reveal the presence of an okadaic acid-sensitive pathway in neurite outgrowth and imply that protein phosphatase plays a positive role in regulating the neuritogenic effects of NGE. Okadaic acid significantly increased phosphorylation of CaMKII; indicating a major role of PP1 in CaMKII dephosphorylation. Literature in this Area Tocris offers the following scientific literature in this area to showcase our products. Abstract: Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro. Okadaic acid promotes epithelial‐mesenchymal transition of hepatocellular carcinoma cells by inhibiting protein phosphatase 2A.

The small subunit ADP-glucose pyrophosphorylase (ApS) promoter mediates okadaic acid-sensitive uidA expression in starch-synthesizing tissues and cells in​  Blood Platelets · diethyltoluamide · Excessive crying infant · Platelet Count measurement · GPER protein, human · Nucleotide Excision Repair · Okadaic Acid  20 dec.

[Okadaic Acid] .We manufacture and distribute chemical reagents for research use only or various antibodies.

OA was named from the marine sponge Halichondria okadai, from which OA was isolated for the first time. It has also been isolated from another marine sponge, H. malanodocia, as a cytotoxin. Okadaic Acid.

27 May 2015 Okadaic acid (OA) is a marine polyether cytotoxin that was first isolated from the marine sponge Halichondria okadai. OA is a potent inhibitor of 

Subscribe to our free newsletters to receive latest health news and alerts to your email inbox. Okadaic acid. Apoptosis Inducer & Phosphatase Inhibitor; induces apoptosis e.g. in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Buy Okadaic Acid Sodium Salt - an affordable, high quality PP1 Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide. Okadaic Acid is one of the toxins associated with diarrheic shellfish poisoning ( DSP).

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Application Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor: • to inhibit protein phosphatase 2 in spermatocytes culture • to treat SH-SY5Y cells to prevent dephosphorylation to maintain tau Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae which causes diarrhetic shellfish poisoning.

1,3 Presumably through these Okadaic acid is a causative agent of diarrhetic shellfish poisoning isolated from the sponge Halichondria Okadai. Okadaic Acid exhibits various activities as follows: Contractile effect on smooth muscles in Ca 2+ free solution. Non-TPA type promoting agent of carcinogenesis.
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EuroProxima Okadaic Acid is a competitive enzyme immunoassay for quantitative analysis of domoic acid in scallop, mussel and oyster samples. General information: High concentrations of shellfish toxins can accumulate in filter feeders such as clams, mussels, and oysters causing illness amongst people who eat them.

This toxin potently and specifically inhibits PP-1 and PP-2A, although with different IC 50 concentrations. Despite sharing similar structure and catalytic The three main results of the study were as follows: (1) The saxitoxin-group toxins, okadaic acid and analogues, and pectenotoxins were the major phycotoxin residues found in scallops; (2) Six kinds of toxic microalgae were identified, Protoperidinium spp., Gonyaulax spp., and Alexandrium spp. were the dominant taxa; Seven types of potential Okadaic acid (or okadeic acid, CAS 78111-17-8, C 44 H 68 O 13) is produced by dinoflagelates Dinophysis sp.